Journal: Scientific Reports
Article Title: Cheminformatics-based design and biomedical applications of a new Hydroxyphenylcalix[4] resorcinarene as anti-cancer agent
doi: 10.1038/s41598-024-82115-1
Figure Lengend Snippet: Cytotoxic effects of HPCR and Cisplatin against normal cells; human dermal fibroblast (HDF) and cancerous cell lines including breast cancer (MCF-7), non-small cell lung cancer (A549) and glioblastoma (U-87 MG) upon 96 h treatment period. The treatment was carried out at the respective IC 50 of HPCR for each cell line (HDF; 146.7 ± 12, MCF-7; 112.3 ± 5.4, A549; 92.3 ± 7.3 and U- 87 MG; 71 ± 10) as well as cisplatin (HDF; 40.9 ± 5.4, MCF-7; 26.9 ± 4.7, A549; 30.4 ± 5.2and U- 87 MG; 28.3 ± 5.3) (40 × objective lens, total magnification = 400x).
Article Snippet: The breast cancer (MCF-7), non-small cell lung cancer (A549), glioblastoma (U-87 MG) and normal human dermal fibroblast (HDF) cell lines were obtained from American Type Culture Collection (ATCC, Manassas, United States).
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